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Chemical structure of NF 449

GC11326

NF 449

Also known as octasodium;4-[[3-[[3,5-bis[(2,4-disulfonatophenyl)carbamoyl]phenyl]carbamoylamino]-5-[(2,4-disulfonatophenyl)carbamoyl]benzoyl]amino]benzene-1,3-disulfonate

NF 449 is a highly potent P2X1 receptor antagonist, with IC50s of 0·28, 0·69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively

ChemicalCAS627034-85-9MW1505.06FormulaC41H24N6Na8O29S8
CAS number
627034-85-9
Molecular weight
1505.06
Formula
C41H24N6Na8O29S8
Solubility
PBS (pH 7·2)： 10 mg/ml
InChIKey
KCBZSNWCUJBMHF-UHFFFAOYSA-F
Catalogue number
GC11326
Brand
GLPBIO
Computed properties PubChem CID 6093161 · TPSA 682 Ų · H-bond donors 6 · H-bond acceptors 29
TPSA
682 Ų
H-bond donors
6
H-bond acceptors
29
Rotatable bonds
10
Heavy atoms
92

SMILES C1=CC(=C(C=C1S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C2=CC(=CC(=C2)NC(=O)NC3=CC(=CC(=C3)C(=O)NC4=C(C=C(C=C4)S(=O)(=O)[O-])S(=O)(=O)[O-])C(=O)NC5=C(C=C(C=C5)S(=O)(=O)[O-])S(=O)(=O)[O-])C(=O)NC6=C(C=C(C=C6)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Computed descriptors from PubChem (CID 6093161), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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