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Chemical structure of Decernotinib(VX-509)

GC10770

Decernotinib(VX-509)

Also known as (2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-(2,2,2-trifluoroethyl)butanamide

Decernotinib(VX-509) is a potent, orally active JAK3 inhibitor, with Kis of 2·5, 11, 13 and 11 nM for JAK3, JAK1, JAK2, and TYK2, respectively

ChemicalCAS944842-54-0MW392.38FormulaC18H19F3N6O
CAS number
944842-54-0
Molecular weight
392.38
Formula
C18H19F3N6O
Solubility
≥ 16·95mg/mL in DMSO
InChIKey
ASUGUQWIHMTFJL-QGZVFWFLSA-N
Catalogue number
GC10770
Brand
GLPBIO
Computed properties PubChem CID 59422203 · XLogP 3.1 · TPSA 95.6 Ų · H-bond donors 3
XLogP
3.1
TPSA
95.6 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
28

SMILES CC[C@](C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3

Computed descriptors from PubChem (CID 59422203), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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