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Chemical structure of BDA-366

GC10721

BDA-366

Also known as 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-oxiran-2-yl]methylamino]anthracene-9,10-dione

BDA-366 is a potent Bcl2 antagonist (Ki = 3·3 nM), binding Bcl2-BH4 domain with high affinity and selectivity· BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer· BDA-366 suppresses growth of lung cancer cells

ChemicalCAS1909226-00-1MW423.5FormulaC24H29N3O4
CAS number
1909226-00-1
Molecular weight
423.5
Formula
C24H29N3O4
Solubility
Soluble in DMSO
InChIKey
JYOOEVFJWLBLKF-HOTGVXAUSA-N
Catalogue number
GC10721
Brand
GLPBIO
Computed properties PubChem CID 91826545 · XLogP 3.8 · TPSA 94.2 Ų · H-bond donors 3
XLogP
3.8
TPSA
94.2 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
10
Heavy atoms
31

SMILES CCN(CC)C[C@H](CNC1=C2C(=C(C=C1)NC[C@H]3CO3)C(=O)C4=CC=CC=C4C2=O)O

Computed descriptors from PubChem (CID 91826545), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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