GC10496
Midostaurin (PKC412)
Also known as N-[(15R,16S,17R,18S)-17-methoxy-17,18-dimethyl-5-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaen-16-yl]-N-methylbenzamide
Midostaurin (PKC412) (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor· Midostaurin (PKC412) inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM· Midostaurin (PKC412) also upregulates endothelial nitric oxide synthase (eNOS) gene expression· Midostaurin (PKC412) shows powerful anticancer effects
- CAS number
- 120685-11-2
- Molecular weight
- 570.64
- Formula
- C35H30N4O4
- Solubility
- ≥ 57·1mg/mL in DMSO with ultrasonic
- InChIKey
- IIQIEMHSDLLZQA-QZPVEUDVSA-N
- Catalogue number
- GC10496
- Brand
- GLPBIO
Computed properties PubChem CID 104937 · XLogP 4.7 · TPSA 77.7 Ų · H-bond donors 1
- XLogP
- 4.7
- TPSA
- 77.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 43
SMILES C[C@]1([C@@H]([C@@H]2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)[C@]1(O2)C)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Computed descriptors from PubChem (CID 104937), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il