GC10405
Methotrexate
Also known as (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
Methotrexate is an antifolate antimetabolite that effectively inhibits the activity of dihydrofolate reductase (DHFR), with an IC50 of approximately 7nM
ChemicalCAS59-05-2MW454.44FormulaC20H22N8O5
- CAS number
- 59-05-2
- Molecular weight
- 454.44
- Formula
- C20H22N8O5
- Solubility
- ≥ 21·55 mg/mL in DMSO
- InChIKey
- FBOZXECLQNJBKD-ZDUSSCGKSA-N
- Catalogue number
- GC10405
- Brand
- GLPBIO
Computed properties PubChem CID 126941 · XLogP -1.8 · TPSA 211 Ų · H-bond donors 5
- XLogP
- -1.8
- TPSA
- 211 Ų
- H-bond donors
- 5
- H-bond acceptors
- 12
- Rotatable bonds
- 9
- Heavy atoms
- 33
SMILES CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Computed descriptors from PubChem (CID 126941), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il