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Chemical structure of Losartan Potassium (DuP 753)

GC10257

Losartan Potassium (DuP 753)

Losartan Potassium (DuP 753) (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM

ChemicalCAS124750-99-8MW462.01FormulaC22H23ClKN6O
CAS number
124750-99-8
Molecular weight
462.01
Formula
C22H23ClKN6O
Solubility
≥ 21·35mg/mL in DMSO
InChIKey
FDKIDFYIEWFERB-UHFFFAOYSA-N
Catalogue number
GC10257
Brand
GLPBIO
Computed properties PubChem CID 9847164 · TPSA 92.5 Ų · H-bond donors 2 · H-bond acceptors 5
TPSA
92.5 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
8
Heavy atoms
31

SMILES CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl.[K]

Computed descriptors from PubChem (CID 9847164), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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