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Chemical structure of Dacomitinib

GC10225

Dacomitinib

Also listed as Dacomitinib (PF299804, PF299)

Dacomitinib (PF299804, PF299) (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45·7 nM and 73·7 nM for EGFR, ERBB2, and ERBB4, respectively

ChemicalCAS1110813-31-4MW469.94FormulaC24H25ClFN5O2
CAS number
1110813-31-4
Molecular weight
469.94
Formula
C24H25ClFN5O2
Solubility
≥ 23·5mg/mL in DMSO, ≥ 8·76 mg/mL in EtOH with ultrasonic and warming
InChIKey
LVXJQMNHJWSHET-AATRIKPKSA-N
Catalogue number
GC10225
Brand
GLPBIO
Computed properties PubChem CID 11511120 · XLogP 4.4 · TPSA 79.4 Ų · H-bond donors 2
XLogP
4.4
TPSA
79.4 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
33

SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4

Computed descriptors from PubChem (CID 11511120), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.