GC10211
FLI-06
Also known as cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate
FLI-06 is a Notch signaling inhibitor (EC50 = 2·3µM) that acts upstream of α-secretase and β-secretase cleavage· FLI-06 disrupts intracellular trafficking and processing of the Notch signaling pathway, inhibiting general secretion at a stage prior to exiting the endoplasmic reticulum (ER) and transforming the ER morphology from tubules to lamellae· FLI-06 for the treatment of cancer and neurodegenerative diseases
- CAS number
- 313967-18-9
- Molecular weight
- 438.52
- Formula
- C25H30N2O5
- Solubility
- ≥ 16·1mg/mL in DMSO
- InChIKey
- SWWVFYHSSOWZMF-UHFFFAOYSA-N
- Catalogue number
- GC10211
- Brand
- GLPBIO
Computed properties PubChem CID 3103157 · XLogP 4.9 · TPSA 101 Ų · H-bond donors 1
- XLogP
- 4.9
- TPSA
- 101 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 32
SMILES CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4
Computed descriptors from PubChem (CID 3103157), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il