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Chemical structure of Ro 31-8220 methanesulfonate

GC10029

Ro 31-8220 methanesulfonate

Also known as methanesulfonic acid;3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propyl carbamimidothioate

Ro 31-8220 methanesulfonate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively

ChemicalCAS138489-18-6MW553.65FormulaC26H27N5O5S2
CAS number
138489-18-6
Molecular weight
553.65
Formula
C26H27N5O5S2
Solubility
DMF： 25 mg/ml,DMF：PBS (pH 7·2) (1：9)： 0·1 mg/ml,DMSO： 20 mg/ml
InChIKey
SAWVGDJBSPLRRB-UHFFFAOYSA-N
Catalogue number
GC10029
Brand
GLPBIO
Computed properties PubChem CID 11628205 · TPSA 194 Ų · H-bond donors 4 · H-bond acceptors 7
TPSA
194 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
38

SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O

Computed descriptors from PubChem (CID 11628205), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.