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Chemical structure of ZB716

GB40424

ZB716

Also known as [(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl]boronic acid

ZB716 is a steroidal, orally bioavailable SERD (selective estrogen receptor downregulator) that binds to ER with high affinity and exerts its antiestrogenic effect on ER-expressing breast cancer cells· In both tamoxifen-naive and tamoxifen-resistant breast cancer cells, ZB716 potently inhibits cell proliferation and effectively degrades the hormone receptor in a dose-dependent manner· ZB716 is shown to have far superior oral bioavailability in mice when compared to fulvestrant·* Sold in collaboration with Zenopharm, LLC

ChemicalCAS1853279-29-4MW634.59FormulaC32H48BF5O4S
CAS number
1853279-29-4
Molecular weight
634.59
Formula
C32H48BF5O4S
InChIKey
FIAYIYKWRBIBQG-GDWZZRAASA-N
Catalogue number
GB40424
Brand
GLPBIO
Computed properties PubChem CID 126480615 · TPSA 97 Ų · H-bond donors 3 · H-bond acceptors 10
TPSA
97 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
15
Heavy atoms
43

SMILES B(C1=CC2=C(C=C1)[C@H]3CC[C@]4([C@H]([C@@H]3[C@@H](C2)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F)CC[C@@H]4O)C)(O)O

Computed descriptors from PubChem (CID 126480615), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.