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Chemical structure of WAY 262611 dihydrochloride

GB40410

WAY 262611 dihydrochloride

Also known as [1-(4-naphthalen-2-ylpyrimidin-2-yl)piperidin-4-yl]methanamine;dihydrochloride

Inhibitor of Dickkopf-1 (DKK1); WAY 262611 is a wingless Wnt/β-Catenin signaling agonist with an inhibitory effect on DKK1, displaying an EC50 value of 0·63 μM for DKK1-mediated TCF-Luciferase, no affinity for GSK-3β (IC50 value >100 μM) and enhancing the bone formation rate in ovariectomized (OVX) rats following oral adminstration· Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development· It regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow, and Kremen2 (Kr2) simultaneously

ChemicalCAS2108968-58-5MW391.34FormulaC20H22N4·2HCl
CAS number
2108968-58-5
Molecular weight
391.34
Formula
C20H22N4·2HCl
InChIKey
VKWQTBHLUZTWQS-UHFFFAOYSA-N
Catalogue number
GB40410
Brand
GLPBIO
Computed properties PubChem CID 91826502 · TPSA 55 Ų · H-bond donors 3 · H-bond acceptors 4
TPSA
55 Ų
H-bond donors
3
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
26

SMILES C1CN(CCC1CN)C2=NC=CC(=N2)C3=CC4=CC=CC=C4C=C3.Cl.Cl

Computed descriptors from PubChem (CID 91826502), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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