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Chemical structure of SGI 1027 dihydrochloride

GB40366

SGI 1027 dihydrochloride

Also listed as SGI 1027 dihydrochloride - S 1027 dihydrochloride

SGI 1027 inhibits DNMT activity (IC50 values 35 μM and 10 μM for DNMT1 and DNMT3A2/3L, respectively) in colon cancer cell lines, and was shown to degrade the enzymes· Prolonged treatment of RKO cells with SGI 1027 led to demethylation and reexpression of the silenced tumor suppressor genes (TSGs) P16, MLH1, and TIMP3 and did not exhibit significant toxicity in a rat hepatoma (H4IIE) cell line· SGI 1027 shows moderate affinity (IC 50 value 65 μM) for G9a-like protein (GLP), another AdoMet-dependent enzyme, as well

ChemicalCAS2108487-01-8MW534.44FormulaC27H25Cl2N7O
CAS number
2108487-01-8
Molecular weight
534.44
Formula
C27H25Cl2N7O
InChIKey
YHBVRBOEKSJVML-UHFFFAOYSA-N
Catalogue number
GB40366
Brand
GLPBIO
Computed properties PubChem CID 91826513 · TPSA 118 Ų · H-bond donors 6 · H-bond acceptors 7
TPSA
118 Ų
H-bond donors
6
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
37

SMILES CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54.Cl.Cl

Computed descriptors from PubChem (CID 91826513), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.