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Chemical structure of Phosphoramidon

GB40322

Phosphoramidon

Also known as disodium;(2S)-3-(1H-indol-3-yl)-2-[[(2S)-4-methyl-2-[[oxido-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphosphoryl]amino]pentanoyl]amino]propanoate

Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24·11 (NEP; Neprilysin; EC 3·4·24·11), Ki=2 nM· Also inhibits neprilysin 2 (Ki~2 nM)· Also inhibits endothelin-converting enzyme (IC50 = 0·68 μM)· Induces a dramatic increase in amyloid-beta levels in rodents

ChemicalCAS119942-99-3MW587.47FormulaC23H32N3Na2O10P
CAS number
119942-99-3
Molecular weight
587.47
Formula
C23H32N3Na2O10P
InChIKey
OQKHVXFOYFBMDJ-ODIUWQMJSA-L
Catalogue number
GB40322
Brand
GLPBIO
Computed properties PubChem CID 16219931 · TPSA 216 Ų · H-bond donors 6 · H-bond acceptors 11
TPSA
216 Ų
H-bond donors
6
H-bond acceptors
11
Rotatable bonds
10
Heavy atoms
39

SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OP(=O)(N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)[O-])[O-])O)O)O.[Na+].[Na+]

Computed descriptors from PubChem (CID 16219931), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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