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Chemical structure of NSC194598

GB40300

NSC194598

Also known as 2-oxido-3-(piperidin-1-ylmethyl)-4-aza-2-azoniatetracyclo[7.6.1.05,16.010,15]hexadeca-1,3,5,7,9(16),10,12,14-octaene

NSC194598 is a p53 DNA-binding inhibitor with an in vitro IC50 value of 180 nM· NSC194598 selectively inhibited DNA binding by p53 and homologs p63/p73, but did not affect E2F1, TCF1, and c-Myc· Furthermore, NSC194598 suppressed p53 transcriptional output after DNA damage in culture and increased the survival of mice after irradiation

ChemicalCAS5358-76-9MW317.38FormulaC20H19N3O
CAS number
5358-76-9
Molecular weight
317.38
Formula
C20H19N3O
Solubility
DMSO ： 8·3 mg/mL (26·15 mM; Need ultrasonic and warming)
InChIKey
XLBPYZGSLNDDSB-UHFFFAOYSA-N
Catalogue number
GB40300
Brand
GLPBIO
Computed properties PubChem CID 3246550 · XLogP 2.6 · TPSA 41.6 Ų · H-bond donors 0
XLogP
2.6
TPSA
41.6 Ų
H-bond donors
0
H-bond acceptors
3
Rotatable bonds
2
Heavy atoms
24

SMILES C1CCN(CC1)CC2=NC3=CC=CC4=C3C(=[N+]2[O-])C5=CC=CC=C45

Computed descriptors from PubChem (CID 3246550), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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