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Chemical structure of NEO 212 - TMZ-POH

GB40295

NEO 212 - TMZ-POH

Also known as [(4S)-4-prop-1-en-2-ylcyclohexen-1-yl]methyl N-(3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)carbamate

Novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo (IC50 values 5-50 µM for cytotoxicity on glioma cell lines)· NEO 212 causes DNA damage and cell death much more efficiently than TMZ, because linkage with POH increased its biological half-life and thus provided greater opportunity for placement of cytotoxic DNA lesions·NEO212 is a conjugate of temozolomide (TMZ) with the natural product perillyl alcohol (POH) and circumvents TMZ-resistance in multiple cancer cell lines and gliomas

ChemicalCAS1361198-79-9MW372.38FormulaC17H20N6O4
CAS number
1361198-79-9
Molecular weight
372.38
Formula
C17H20N6O4
InChIKey
MGTLGARADRIKNV-GFCCVEGCSA-N
Catalogue number
GB40295
Brand
GLPBIO
Computed properties PubChem CID 56846912 · XLogP 2.8 · TPSA 118 Ų · H-bond donors 1
XLogP
2.8
TPSA
118 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
27

SMILES CC(=C)[C@H]1CCC(=CC1)COC(=O)NC(=O)C2=C3N=NN(C(=O)N3C=N2)C

Computed descriptors from PubChem (CID 56846912), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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