GB40271
MC70 hydrochloride
Also known as 4-[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenyl]phenol;hydrochloride
Potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0·05 μM, 0·69 μM, 9·3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively), with potential as novel anticancer agent with both cytostatic and cytotoxic characteristics· MC70, as an inhibitor of the ABC transporter ABCB1 (aka MDR1), potentiates Doxorubicin efficacy in colon and breast cancer in vitro treatment
ChemicalCAS2108830-71-1MW411.92FormulaC24H25NO3·HCl
- CAS number
- 2108830-71-1
- Molecular weight
- 411.92
- Formula
- C24H25NO3·HCl
- InChIKey
- WVIKMAFTKZTBFM-UHFFFAOYSA-N
- Catalogue number
- GB40271
- Brand
- GLPBIO
Computed properties PubChem CID 121230972 · TPSA 41.9 Ų · H-bond donors 2 · H-bond acceptors 4
- TPSA
- 41.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Rotatable bonds
- 5
- Heavy atoms
- 29
SMILES COC1=C(C=C2CN(CCC2=C1)CC3=CC=C(C=C3)C4=CC=C(C=C4)O)OC.Cl
Computed descriptors from PubChem (CID 121230972), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il