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Chemical structure of LUF7244

GB40265

LUF7244

Also known as 2-[4-(3-chlorobenzoyl)phenoxy]-N-pyridin-3-ylacetamide

LUF7244 is a potent negative allosteric modulator of Kv 11·1 (hERG) channels with an IC50 value of 3·9 μM· Moreover, LUF7244 was found to be a negative allosteric modulator of dofetilide binding to the Kv11·1 channel with the strongest effect at 10 μmol/L

ChemicalCAS1821638-43-0MW366.8FormulaC20H15ClN2O3
CAS number
1821638-43-0
Molecular weight
366.8
Formula
C20H15ClN2O3
InChIKey
KKKJYDOHVKIIQP-UHFFFAOYSA-N
Catalogue number
GB40265
Brand
GLPBIO
Computed properties PubChem CID 127042386 · XLogP 3.7 · TPSA 68.3 Ų · H-bond donors 1
XLogP
3.7
TPSA
68.3 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
26

SMILES C1=CC(=CC(=C1)Cl)C(=O)C2=CC=C(C=C2)OCC(=O)NC3=CN=CC=C3

Computed descriptors from PubChem (CID 127042386), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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