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Chemical structure of LDN 212854 trihydrochloride

GB40259

LDN 212854 trihydrochloride

Also known as 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;trihydrochloride

Potent ALK2-biased BMP type I receptor kinase inhibitor (IC50 values 2·4 nM, 1·3 nM, and 85·8 nM for ALK1, 2, and 3 resp·), showing nearly 4 orders of selectivity for BMP versus the closely related TGF-β and Activin type I receptors· The free base form, LDN 212854 is available as LDN 212854· Closely related to LDN 193189

ChemicalCAS2109414-80-2MW515.87FormulaC25H22N6·3HCl
CAS number
2109414-80-2
Molecular weight
515.87
Formula
C25H22N6·3HCl
InChIKey
RIMSXBSYXNLYPT-UHFFFAOYSA-N
Catalogue number
GB40259
Brand
GLPBIO
Computed properties PubChem CID 91826503 · TPSA 58.4 Ų · H-bond donors 4 · H-bond acceptors 5
TPSA
58.4 Ų
H-bond donors
4
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
34

SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=C6C=CC=NC6=CC=C5)N=C3.Cl.Cl.Cl

Computed descriptors from PubChem (CID 91826503), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.