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Chemical structure of GPI-16552

GB40221

GPI-16552

Also known as 9-oxo-2-N,7-N-bis(3-phenylpropyl)fluorene-2,7-dicarboxamide

GPI-16552 (443794-40-9) is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1·7 μM· Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia· It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma· GPI-16552 synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells

ChemicalCAS443794-40-9MW502.62FormulaC33H30N2O3
CAS number
443794-40-9
Molecular weight
502.62
Formula
C33H30N2O3
InChIKey
OKGPGSVMCACUID-UHFFFAOYSA-N
Catalogue number
GB40221
Brand
GLPBIO
Computed properties PubChem CID 10117946 · XLogP 6.2 · TPSA 75.3 Ų · H-bond donors 2
XLogP
6.2
TPSA
75.3 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
10
Heavy atoms
38

SMILES C1=CC=C(C=C1)CCCNC(=O)C2=CC3=C(C=C2)C4=C(C3=O)C=C(C=C4)C(=O)NCCCC5=CC=CC=C5

Computed descriptors from PubChem (CID 10117946), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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