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Chemical structure of EHNA HCl

GB40191

EHNA HCl

EHNA (51350-19-7) inhibits phosphodiesterase 2 (PDE2) (IC50 = 0·8 - 5·5 µM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 values > 100 µM)· It also inhibits adenosine deaminase (ADA), IC50 = 1·2 and 1·5 µM in human RBCs and astrocytoma cells, respectively, which may be responsible for its ability to induce apoptosis in malignant pleural mesothelioma cell lines· Because it blocks breakdown of adenosine to inosine and hypoxanthine, EHNA prevents formation of free radical substrates, protecting against cardiac reperfusion-mediated injury· It inhibits differentiation and maintains expression of pluripotency markers in hESCs, but not through inhibition of PDEs or ADA

ChemicalCAS51350-19-7MW318.87FormulaC14H28N5O ? HCl
CAS number
51350-19-7
Molecular weight
318.87
Formula
C14H28N5O ? HCl
Solubility
H2O ： 100 mg/mL (318·64 mM; Need ultrasonic); DMSO ： 83·33 mg/mL (265·53 mM; ultrasonic and warming and heat to 60°C)
Catalogue number
GB40191
Brand
GLPBIO

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.