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Chemical structure of E7449 mesylate

GB40190

E7449 mesylate

Also listed as E7449 mesylate - 2X-121

E7449 mesylate is a potent, brain penetrable and orally bioavailable dual inhibitor of PARP1/2 and tankyrase1/2, which inhibits growth of DNA repair deficient tumors and antagonizes Wnt signalling· E7449 mesylate exhibits IC50 values of 2·0 and 1·0 nM for PARP1 and PARP2, respectively

ChemicalCAS1140965-47-4MW413.45FormulaC18H15N5O·CH4O3S
CAS number
1140965-47-4
Molecular weight
413.45
Formula
C18H15N5O·CH4O3S
InChIKey
SQQZCNVWIZVPBE-UHFFFAOYSA-N
Catalogue number
GB40190
Brand
GLPBIO
Computed properties PubChem CID 156600286 · TPSA 132 Ų · H-bond donors 3 · H-bond acceptors 6
TPSA
132 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
2
Heavy atoms
29

SMILES CS(=O)(=O)O.C1C2=CC=CC=C2CN1CC3=NC4=NNC(=O)C5=C4C(=CC=C5)N3

Computed descriptors from PubChem (CID 156600286), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.