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Chemical structure of Divin

GB40181

Divin

Also known as N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]-3-(2-methylbenzimidazol-1-yl)propanamide

Divin (1443321-11-6) is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ· Iron starvation leads to transcriptional down-regulation of genes encoding proteins involved in cell division and affects the spatiotemporal localization of the divisome· Long-term treatment of bacteria with Divin resulted in cellular damage and prevented reactivation of the divisome even in the presence of iron-replete conditions· Iron deprivation is a potential adjuvant therapy for treating bacterial antibiotic resistance

ChemicalCAS1443321-11-6MW372.42FormulaC22H20N4O2
CAS number
1443321-11-6
Molecular weight
372.42
Formula
C22H20N4O2
InChIKey
SOPYTFSYTUAGFR-OEAKJJBVSA-N
Catalogue number
GB40181
Brand
GLPBIO
Computed properties PubChem CID 135641995 · XLogP 3.5 · TPSA 79.5 Ų · H-bond donors 2
XLogP
3.5
TPSA
79.5 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
28

SMILES CC1=NC2=CC=CC=C2N1CCC(=O)N/N=C/C3=C(C=CC4=CC=CC=C43)O

Computed descriptors from PubChem (CID 135641995), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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