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Chemical structure of Dienamide A2

GB40178

Dienamide A2

Also known as (2E,4E)-N-(2-methylpropyl)dodeca-2,4-dienamide

Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds· This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor· Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)· It elevates intracellular Ca levels in CB2-positive but not in CB2-negative cells and this effect was blocked by SR144528· It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner

ChemicalCAS24738-51-0MW251.41FormulaC16H29NO
CAS number
24738-51-0
Molecular weight
251.41
Formula
C16H29NO
InChIKey
BBRMJCAPNGJKEM-AQASXUMVSA-N
Catalogue number
GB40178
Brand
GLPBIO
Computed properties PubChem CID 6443006 · XLogP 5.5 · TPSA 29.1 Ų · H-bond donors 1
XLogP
5.5
TPSA
29.1 Ų
H-bond donors
1
H-bond acceptors
1
Rotatable bonds
10
Heavy atoms
18

SMILES CCCCCCC/C=C/C=C/C(=O)NCC(C)C

Computed descriptors from PubChem (CID 6443006), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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