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Chemical structure of D 106669

GB40167

D 106669

Also known as 1-ethyl-3-[3-(4-methylanilino)pyrido[2,3-b]pyrazin-6-yl]urea

Highly potent and selective PI3K inhibitor, selectively inhibiting class I PI3K (PI3Kα IC50 3 log selectivity against tyrosine or serine/threonine kinases, except ERK1 and 2) and showed some activity in A549 (lung cancer) xenografts mouse model at oral dose of 30 mg/kg twice daily

ChemicalCAS938444-93-0MW322.36FormulaC17H18N6O
CAS number
938444-93-0
Molecular weight
322.36
Formula
C17H18N6O
InChIKey
RQBRFKKFZPOBFG-UHFFFAOYSA-N
Catalogue number
GB40167
Brand
GLPBIO
Computed properties PubChem CID 16048654 · XLogP 2.4 · TPSA 91.8 Ų · H-bond donors 3
XLogP
2.4
TPSA
91.8 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
24

SMILES CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CC=C(C=C3)C

Computed descriptors from PubChem (CID 16048654), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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