GB40155
CP 346086
Potent microsomal triglyceride transfer protein (MTP, MTTP) inhibitor that inhibits both human and rodent MTP activity (IC50 value 2·0 nM)· After a 2 week treatment CP 346086 reduced total and LDL cholesterol and triglycerides by 47%, 72%, and 75%, relative to either individual baselines or placebo, with little change in HDL cholesterol· More potent in MTP inhibition than SLX 4090 and Lomitapide (Juxtapid; IC50 value 8 nM and 5-7 nM respectively)
ChemicalCAS186390-48-7MW477.48FormulaC26H22F3N5O
- CAS number
- 186390-48-7
- Molecular weight
- 477.48
- Formula
- C26H22F3N5O
- Solubility
- DMSO ： 100 mg/mL (209·43 mM; Need ultrasonic)
- Catalogue number
- GB40155
- Brand
- GLPBIO
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il