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Chemical structure of Compound 115-7c

GB40151

Compound 115-7c

Also known as 4-[6-(2,4-dichlorophenyl)-4-methyl-2-oxo-5-phenylmethoxycarbonyl-1,6-dihydropyrimidin-3-yl]butanoic acid

Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70· The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70· Increases tau levels in cell lines overexpressing tau· Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity· Compound 115-7c is an important probe for understanding HSP70 functions

ChemicalCAS908074-72-6MW477.34FormulaC23H22Cl2N2O5
CAS number
908074-72-6
Molecular weight
477.34
Formula
C23H22Cl2N2O5
InChIKey
UHBVLBSCOSTTAV-UHFFFAOYSA-N
Catalogue number
GB40151
Brand
GLPBIO
Computed properties PubChem CID 5461551 · XLogP 3.8 · TPSA 95.9 Ų · H-bond donors 2
XLogP
3.8
TPSA
95.9 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
9
Heavy atoms
32

SMILES CC1=C(C(NC(=O)N1CCCC(=O)O)C2=C(C=C(C=C2)Cl)Cl)C(=O)OCC3=CC=CC=C3

Computed descriptors from PubChem (CID 5461551), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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