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Chemical structure of CLK8

GB40148

CLK8

Also known as 2-[[2-[(8,8-dimethyl-2-oxo-4-phenyl-9,10-dihydropyrano[2,3-h]chromen-5-yl)oxy]acetyl]amino]benzamide

CLK8, a specific CLOCK-binding small molecule, inhibits the interaction between CLOCK and BMAL1 and interferes with nuclear translocation of CLOCK both in vivo and in vitro· CLK8 can be used to enhance circadian rhythm·Keywords: CLK8 | supplier | CLOCK/BMAL1 inhibitor | CLK 8 | CLK-8 | CAS [898920-65-5] | DNA-RNA | CLOCK | Inhibitor | Transcription Factors | Circadian rhythm amplitude regulation | Brain and muscle Arnt-like protein-1 | BMAL1

ChemicalCAS898920-65-5MW498.53FormulaC29H26N2O6
CAS number
898920-65-5
Molecular weight
498.53
Formula
C29H26N2O6
Solubility
DMSO ： 50 mg/mL (100·29 mM; Need ultrasonic)
InChIKey
SVELPNHVEDZZRQ-UHFFFAOYSA-N
Catalogue number
GB40148
Brand
GLPBIO
Computed properties PubChem CID 4869040 · XLogP 4.4 · TPSA 117 Ų · H-bond donors 2
XLogP
4.4
TPSA
117 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
37

SMILES CC1(CCC2=C3C(=C(C=C2O1)OCC(=O)NC4=CC=CC=C4C(=O)N)C(=CC(=O)O3)C5=CC=CC=C5)C

Computed descriptors from PubChem (CID 4869040), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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