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Chemical structure of CD161

GB40142

CD161

Also known as 4-(6-methoxy-2-methyl-4-quinolin-4-yl-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethyl-1,2-oxazole

CD161 is a potent, orally active and selective BET bromodomain inhibitor (Ki values of 8·2 nM and 1·4 nM for BRD4 BD1 and BD2, respectively)· CD161 inhibits cell growth in acute leukemia cell lines and breast cancer cell lines· Moreover, CD161 has an excellent oral pharmacokinetic profile and, orally administered, effectively inhibits tumor growth in mice

ChemicalCAS1627716-22-6MW435.48FormulaC26H21N5O2
CAS number
1627716-22-6
Molecular weight
435.48
Formula
C26H21N5O2
InChIKey
AEANZCXROGPSBY-UHFFFAOYSA-N
Catalogue number
GB40142
Brand
GLPBIO
Computed properties PubChem CID 90395752 · XLogP 5.2 · TPSA 89.7 Ų · H-bond donors 1
XLogP
5.2
TPSA
89.7 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
33

SMILES CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)NC4=NC(=NC(=C34)C5=CC=NC6=CC=CC=C56)C)OC

Computed descriptors from PubChem (CID 90395752), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.