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Chemical structure of BML283

GB40127

BML283

Also known as 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(4-methoxyphenyl)sulfonylpiperazine

BML283 (562867-96-3) is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) - AC50 = 111nM· PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and an increase in anabolic metabolism· BML283 is an important tool for studying the effects of PKM2 and cancer metabolism

ChemicalCAS562867-96-3MW454.51FormulaC19H22N2O7S2
CAS number
562867-96-3
Molecular weight
454.51
Formula
C19H22N2O7S2
InChIKey
HMGDKYUJSFVHIY-UHFFFAOYSA-N
Catalogue number
GB40127
Brand
GLPBIO
Computed properties PubChem CID 650361 · XLogP 1.4 · TPSA 119 Ų · H-bond donors 0
XLogP
1.4
TPSA
119 Ų
H-bond donors
0
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
30

SMILES COC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OCCO4

Computed descriptors from PubChem (CID 650361), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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