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Chemical structure of AZD 2858 hydrochloride

GB40110

AZD 2858 hydrochloride

Also known as 3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridin-3-ylpyrazine-2-carboxamide;hydrochloride

Potent and highly selective Glycogen Synthase Kinase-3β (GSK-3β; Ki value 4·9 nM) inhibitor for Alzheimer's disease with good BBB permeability in a bovine endothelial cell assay· AZD 2858 inhibits GSK-3β-mediated tau phosphorylation (IC50 value 76 nM) in vitro, and shows a good overall selectivity versus a panel of 26 kinases and >100 fold selectivity over CDK2 (Ki value 540 nM)·In rats, oral AZD2858 treatment caused a dose-dependent increase in trabecular bone mass by GSK-3 mediated inhibition of Wnt canonical signaling, making AZD2858 a possible therapeutic candidate for osteoporosis

ChemicalCAS2108876-05-5MW489.98FormulaC21H23N7O3S·HCl
CAS number
2108876-05-5
Molecular weight
489.98
Formula
C21H23N7O3S·HCl
InChIKey
JZZQOCSQIDAFGQ-UHFFFAOYSA-N
Catalogue number
GB40110
Brand
GLPBIO
Computed properties PubChem CID 10300031 · TPSA 143 Ų · H-bond donors 3 · H-bond acceptors 9
TPSA
143 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
33

SMILES CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N.Cl

Computed descriptors from PubChem (CID 10300031), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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