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Chemical structure of ARM1 hydrobromide

GB40104

ARM1 hydrobromide

Also known as 4-(4-benzylphenyl)-1,3-thiazol-2-amine;hydrobromide

Novel type of LTA4H inhibitor (IC50 value of ~0·5 μM in human neutrophils, and Ki value of 2·3 μM for purified LTA4H) that selectively blocks the conversion of LTA4 into proinflammatory mediator LTB4, although leaving the aminopeptidase activity intact for cleavage and inactivation of Pro-Gly-Pro· About LTA4H: Leukotriene A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases· Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme's endogenous peptidase substrate

ChemicalCAS1049743-03-4MW347.27FormulaC16H14N2S·HBr
CAS number
1049743-03-4
Molecular weight
347.27
Formula
C16H14N2S·HBr
InChIKey
JNODWABIDXRUJK-UHFFFAOYSA-N
Catalogue number
GB40104
Brand
GLPBIO
Computed properties PubChem CID 16495486 · TPSA 67.2 Ų · H-bond donors 2 · H-bond acceptors 3
TPSA
67.2 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
3
Heavy atoms
20

SMILES C1=CC=C(C=C1)CC2=CC=C(C=C2)C3=CSC(=N3)N.Br

Computed descriptors from PubChem (CID 16495486), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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