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Chemical structure of ARB-272572 - PD-L1 inhibitor compound A

GB40103

ARB-272572 - PD-L1 inhibitor compound A

Also known as 5-[(2-hydroxyethylamino)methyl]-N-[3-[3-[[5-[(2-hydroxyethylamino)methyl]pyridine-2-carbonyl]amino]-2-methylphenyl]-2-methylphenyl]pyridine-2-carboxamide

ARB-272572 is a potent, cellular active PD-L1 inhibitor with an IC50 value of 400 pM for inhibition of PD-1/PD-L1 cell signaling (HTRF assay)· ARB-272572 inhibits the PD-1/PD-L1 A1is by inducing cell surface PD-L1 dimerization followed by rapid internalization into the cytosol· In addition, ARB-272572 is the first small-molecule checkpoint inhibitor inducing T cell proliferative and IFNγ responses to HBV peptides

ChemicalCAS2368182-63-0MW568.67FormulaC32H36N6O4
CAS number
2368182-63-0
Molecular weight
568.67
Formula
C32H36N6O4
InChIKey
FZEPAZRIEAMJFE-UHFFFAOYSA-N
Catalogue number
GB40103
Brand
GLPBIO
Computed properties PubChem CID 139537190 · XLogP 1.8 · TPSA 149 Ų · H-bond donors 6
XLogP
1.8
TPSA
149 Ų
H-bond donors
6
H-bond acceptors
8
Rotatable bonds
13
Heavy atoms
42

SMILES CC1=C(C=CC=C1NC(=O)C2=NC=C(C=C2)CNCCO)C3=C(C(=CC=C3)NC(=O)C4=NC=C(C=C4)CNCCO)C

Computed descriptors from PubChem (CID 139537190), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Lead time
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.