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Chemical structure of AI-1

GB40096

AI-1

Also known as ethyl 4-chloro-1-methyl-2-oxoquinoline-3-carboxylate

AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2· Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2· AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology· Cell permeable

ChemicalCAS75483-04-4MW265.7FormulaC13H12ClNO3
CAS number
75483-04-4
Molecular weight
265.7
Formula
C13H12ClNO3
InChIKey
XUJQDJGGHFNYDY-UHFFFAOYSA-N
Catalogue number
GB40096
Brand
GLPBIO
Computed properties PubChem CID 606180 · XLogP 2.3 · TPSA 46.6 Ų · H-bond donors 0
XLogP
2.3
TPSA
46.6 Ų
H-bond donors
0
H-bond acceptors
3
Rotatable bonds
3
Heavy atoms
18

SMILES CCOC(=O)C1=C(C2=CC=CC=C2N(C1=O)C)Cl

Computed descriptors from PubChem (CID 606180), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.