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Chemical structure of AA43279

GB40087

AA43279

Also known as 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxamide

AA43279 (354812-16-1) is a selective Nav1·1 activator· In HEK-293 cells expressing human Nav1·1 channels AA43279 increased the Nav1·1-mediated current in a concentration dependent manner (EC50=9·5 μM)· In rat hippocampal brain slices it increased the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons· It displayed anticonvulsant activity in vivo· Important tool compound for exploring the physiology of Nav1·1 channels

ChemicalCAS354812-16-1MW248.3FormulaC12H12N2O2S
CAS number
354812-16-1
Molecular weight
248.3
Formula
C12H12N2O2S
InChIKey
OEUITKOCUWEFOB-UHFFFAOYSA-N
Catalogue number
GB40087
Brand
GLPBIO
Computed properties PubChem CID 4278270 · XLogP 2.3 · TPSA 107 Ų · H-bond donors 2
XLogP
2.3
TPSA
107 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
17

SMILES COC1=CC=C(C=C1)C2=CC(=C(S2)C(=O)N)N

Computed descriptors from PubChem (CID 4278270), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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