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Chemical structure of 2GBI

GB40069

2GBI

Also known as 2-(1H-benzimidazol-2-yl)guanidine

2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1)· 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side· Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease

ChemicalCAS5418-95-1MW175.19FormulaC8H9N5
CAS number
5418-95-1
Molecular weight
175.19
Formula
C8H9N5
InChIKey
JJWCTKUQWXYIIU-UHFFFAOYSA-N
Catalogue number
GB40069
Brand
GLPBIO
Computed properties PubChem CID 36149 · XLogP 0.1 · TPSA 93.1 Ų · H-bond donors 3
XLogP
0.1
TPSA
93.1 Ų
H-bond donors
3
H-bond acceptors
2
Rotatable bonds
1
Heavy atoms
13

SMILES C1=CC=C2C(=C1)NC(=N2)N=C(N)N

Computed descriptors from PubChem (CID 36149), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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