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Chemical structure of (+)-ZK 216348

GB40042

(+)-ZK 216348

Also known as 4-(2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamide

Selective nonsteroidal glucocorticoid receptor (GR) agonist for the treatment of experimental colitis with IC50 values of 20, 20, and 80 nM for GR, Progesterone (PR) and Mineralocorticoid (MR) receptors respectively· (+)-ZK 216348 shows antiinflammatory activity comparable to prednisolone for both systemic and topical application, with a significant dissociation between transrepression and transactivation of antiinflammatory effects both in vitro and in vivo·(+)-ZK 216348 showed no negative effects on intestinal epithelial migration or proliferation· (-)-ZK 216348 is completely inactive (IC50 >1000 nM for GR, PR, and MR

ChemicalCAS669073-68-1MW476.45FormulaC24H23F3N2O5
CAS number
669073-68-1
Molecular weight
476.45
Formula
C24H23F3N2O5
Solubility
DMSO ： 200 mg/mL (419·77 mM; Need ultrasonic)
InChIKey
VRZVKIJRJRBQJT-UHFFFAOYSA-N
Catalogue number
GB40042
Brand
GLPBIO
Computed properties PubChem CID 9805004 · XLogP 4.3 · TPSA 97.2 Ų · H-bond donors 2
XLogP
4.3
TPSA
97.2 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
34

SMILES CC1=NOC(=O)C2=C1C=C(C=C2)NC(=O)C(CC(C)(C)C3=CC=CC4=C3OCC4)(C(F)(F)F)O

Computed descriptors from PubChem (CID 9805004), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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