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Chemical structure of (d(CH?)?¹,Tyr(Me)²,Dab?,Arg?)-Vasopressin

GA24029

(d(CH?)?¹,Tyr(Me)²,Dab?,Arg?)-Vasopressin

Also known as (2S)-1-[(10R,13S,16S,19S,22S)-13-(2-aminoethyl)-16-(3-amino-3-oxopropyl)-19-benzyl-22-[(4-methoxyphenyl)methyl]-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

The isosteric substitution of Asn5 by Dab in oxytocin, vasopressin and their analogs invariably leads to a dramatic loss of the biolical activities of the peptides

ChemicalCAS176714-12-8MW1137.38
CAS number
176714-12-8
Molecular weight
1137.38
Formula
InChIKey
INVLKWYRRAYQNG-OAKHNGAUSA-N
Catalogue number
GA24029
Brand
GLPBIO
Computed properties PubChem CID 102510001 · XLogP -1.5 · TPSA 460 Ų · H-bond donors 12
XLogP
-1.5
TPSA
460 Ų
H-bond donors
12
H-bond acceptors
15
Rotatable bonds
20
Heavy atoms
79

SMILES COC1=CC=C(C=C1)C[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC3(CCCCC3)CC(=O)N2)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N)CCN)CCC(=O)N)CC5=CC=CC=C5

Computed descriptors from PubChem (CID 102510001), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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