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Chemical structure of α-MSH (free acid)

GA23994

α-MSH (free acid)

Also known as (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(1S)-1-carboxy-2-methylpropyl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

α-MSH (free acid) (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC50s of 0·16 nM and 5·6 nM, respectively

ChemicalCAS10466-28-1MW1665.89FormulaC77H108N20O20S
CAS number
10466-28-1
Molecular weight
1665.89
Formula
C77H108N20O20S
Solubility
Soluble in DMSO
InChIKey
MBBQINYFFIKILA-PDEGJNOBSA-N
Catalogue number
GA23994
Brand
GLPBIO
Computed properties PubChem CID 16131203 · XLogP -3.6 · TPSA 662 Ų · H-bond donors 23
XLogP
-3.6
TPSA
662 Ų
H-bond donors
23
H-bond acceptors
24
Rotatable bonds
51
Heavy atoms
118

SMILES CC(C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](CO)NC(=O)C

Computed descriptors from PubChem (CID 16131203), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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