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Chemical structure of Z-Gly-Pro-Arg-AMC · HCl

GA23819

Z-Gly-Pro-Arg-AMC · HCl

Also known as benzyl N-[2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]carbamate;hydrochloride

Z-GPR-AMC is a fluorogenic substrate for cathepsin K, granzyme A, and thrombin· Kinetic data for throbin: kcat = 18·6, Km = 21·7 uM

ChemicalCAS201928-42-9MW656.14FormulaC31H37N7O7 · HCl
CAS number
201928-42-9
Molecular weight
656.14
Formula
C31H37N7O7 · HCl
Solubility
DMSO : 100 mg/mL (152·41 mM; Need ultrasonic)
InChIKey
WIIZWHSOXXZHRC-UKOKCHKQSA-N
Catalogue number
GA23819
Brand
GLPBIO
Computed properties PubChem CID 91873354 · TPSA 208 Ų · H-bond donors 6 · H-bond acceptors 8
TPSA
208 Ų
H-bond donors
6
H-bond acceptors
8
Rotatable bonds
13
Heavy atoms
46

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)CNC(=O)OCC4=CC=CC=C4.Cl

Computed descriptors from PubChem (CID 91873354), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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