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Chemical structure of Z-Asp(OtBu)-bromomethylketone

GA23725

Z-Asp(OtBu)-bromomethylketone

Also known as tert-butyl (3S)-5-bromo-4-oxo-3-(phenylmethoxycarbonylamino)pentanoate

Intermediate for the synthesis of IL-1β converting enzyme (ICE, caspase-1) inhibitors or other inhibitors containing a C-terminal aspartyl residue modified by different methylketone derivatives· According to NÉmeth el al·, who detected an antiapoptotic activity for the compound itself, it may be used for studying the early events of apoptosis in some cell types

ChemicalCAS153088-76-7MW400.27FormulaC17H22BrNO5
CAS number
153088-76-7
Molecular weight
400.27
Formula
C17H22BrNO5
Solubility
Soluble in DMSO
InChIKey
PBVFTOAYKLEQQO-ZDUSSCGKSA-N
Catalogue number
GA23725
Brand
GLPBIO
Computed properties PubChem CID 7020820 · XLogP 2.8 · TPSA 81.7 Ų · H-bond donors 1
XLogP
2.8
TPSA
81.7 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
10
Heavy atoms
24

SMILES CC(C)(C)OC(=O)C[C@@H](C(=O)CBr)NC(=O)OCC1=CC=CC=C1

Computed descriptors from PubChem (CID 7020820), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.