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Chemical structure of Uroguanylin Topoisomer A (human)

GA23661

Uroguanylin Topoisomer A (human)

Also known as (2S)-2-[[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-25-[[(2S)-3-carboxy-2-[[(2S)-3-carboxy-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]propanoyl]amino]-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-di(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecazabicyclo[14.13.13]dotetracontane-38-carbonyl]amino]-4-methylpentanoic acid

Uroguanylin belongs to the guanylin family of cyclic guanosine monophosphate (cGMP) regulating peptides· This family of peptides shows homology to the heat stable enterotoxins produced by strains of Escherichia coli and other enteric bacteria that cause a secretory form of diarrhea· Along with the isolation of uroguanylin from urine and the subsequent demonstration of its natriuretic activity by direct effects on the kidney, uroguanylin has been suggested to play a role in the physiological maintenance of sodium balance in vivo·Uroguanylin activation of the guanylate cyclase-C/cyclic guanosine monophosphate pathway elicited analgesic effects in animal models of colonic hypersensitivity, unraveling a novel pathway to treat abdominal pain (Silos-Santiago et al· (2013))

ChemicalCAS154525-25-4MW1667.88FormulaC64H102N18O26S4
CAS number
154525-25-4
Molecular weight
1667.88
Formula
C64H102N18O26S4
Solubility
Soluble in DMSO
InChIKey
VQZRYOAXGUCZMI-HWMZBCIHSA-N
Catalogue number
GA23661
Brand
GLPBIO
Computed properties PubChem CID 71308576 · XLogP -8.5 · TPSA 819 Ų · H-bond donors 23
XLogP
-8.5
TPSA
819 Ų
H-bond donors
23
H-bond acceptors
31
Rotatable bonds
27
Heavy atoms
112

SMILES C[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N)N

Computed descriptors from PubChem (CID 71308576), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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