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Chemical structure of Somatostatin-28

GA23509

Somatostatin-28

Also known as 37-[[2-[2-[[6-amino-2-[[2-[[2-[[2-[[1-[2-[[2-[2-[[1-[4-amino-2-[[2-[[4-amino-2-[2-[(2-amino-3-hydroxypropanoyl)amino]propanoylamino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]propanoylamino]-4-methylsulfanylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]propanoylamino]acetyl]amino]-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-10,16-bis(1-hydroxyethyl)-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carboxylic acid

The octacosapeptide somatostatin-28 arises from the posttranslational cleavage of prosomatostatin, which in turn is derived from a larger precursor, preprosomatostatin· S-28 was first isolated from porcine duodenum· In guinea-pig pancreatic acini, S-28, unlike S-14, increased amylase secretion, cellular cyclic GMP, and Ca²? outfluxes

ChemicalCAS73032-94-7MW3148.6FormulaC137H207N41O39S3
CAS number
73032-94-7
Molecular weight
3148.6
Formula
C137H207N41O39S3
Solubility
DMSO : 100 mg/mL (31·76 mM; Need ultrasonic)
InChIKey
GGYTXJNZMFRSLX-UHFFFAOYSA-N
Catalogue number
GA23509
Brand
GLPBIO
Computed properties PubChem CID 16132331 · XLogP -15.2 · TPSA 1390 Ų · H-bond donors 46
XLogP
-15.2
TPSA
1390 Ų
H-bond donors
46
H-bond acceptors
48
Rotatable bonds
78
Heavy atoms
220

SMILES CC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)CNC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CO)N)C(=O)O)CO)C(C)O)CC8=CC=CC=C8)O

Computed descriptors from PubChem (CID 16132331), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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