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Chemical structure of RFRP-3 (rat)

GA23481

RFRP-3 (rat)

Also known as (4S)-5-[[(2S)-1-[[2-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-aminopropanoyl]amino]-4-oxobutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoic acid

RFRP-3 belongs to a family of RFamide peptides termed RFamide-related peptides (RFRPs), reported to be present in the mammalian brain· The preproprotein of rat RFRPs contains two putative peptides RFRP-1 and RFRP-3 and it could be demonstrated by K·Ukena et al·, that the octadecapeptide ANMEAGTMSHFPSLPQRF represents the mature form of RFPR-3 in the rat hypothalamus

ChemicalCAS420088-80-8MW2020.32FormulaC88H134N26O25S2
CAS number
420088-80-8
Molecular weight
2020.32
Formula
C88H134N26O25S2
Solubility
Soluble in DMSO
InChIKey
QIJMBTDODJSDJI-YPHUOVQFSA-N
Catalogue number
GA23481
Brand
GLPBIO
Computed properties PubChem CID 90472633 · XLogP -8.9 · TPSA 872 Ų · H-bond donors 27
XLogP
-8.9
TPSA
872 Ų
H-bond donors
27
H-bond acceptors
30
Rotatable bonds
63
Heavy atoms
141

SMILES C[C@H]([C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C)N)O

Computed descriptors from PubChem (CID 90472633), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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