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Chemical structure of Pseudin-2

GA23391

Pseudin-2

Also known as (2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoic acid

Pseudin-2 is a cationic α-helical peptide originally isolated from the skin of the paradoxical frog Pseudis paradoxa on the basis of its antimicrobial activity· GLNALKKVFQGIHEAIKLINNHVQ stimulated insulin secretion from BRIN-BD11 cells by a Ca²?-independent mechanism

ChemicalCAS388602-02-6MW2685.17FormulaC122H202N36O32
CAS number
388602-02-6
Molecular weight
2685.17
Formula
C122H202N36O32
Solubility
Soluble in DMSO
InChIKey
ZPMUCAJJGYDHGH-LPZBDFLVSA-N
Catalogue number
GA23391
Brand
GLPBIO
Computed properties PubChem CID 102602717 · XLogP -9 · TPSA 1120 Ų · H-bond donors 36
XLogP
-9
TPSA
1120 Ų
H-bond donors
36
H-bond acceptors
38
Rotatable bonds
94
Heavy atoms
190

SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CN

Computed descriptors from PubChem (CID 102602717), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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