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Chemical structure of PDGF Antagonist

GA23351

PDGF Antagonist

Also known as (2S)-1-[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-aminopropanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid

The 13-amino acid peptide derived from the primary sequence of the B-chain of PDGF was found to be an antagonist for PDGF α- and β-receptors· The sequence of H-8650, ANFLVWEIVRKKP, combines PDGF-BB 35-40 (loop I) and PDGF-BB 76-82 (loop III)

ChemicalCAS143784-00-3MW1599.94FormulaC77H122N20O17
CAS number
143784-00-3
Molecular weight
1599.94
Formula
C77H122N20O17
Solubility
Soluble in DMSO
InChIKey
GJLDYJFNKAUGHT-HOLLTSQOSA-N
Catalogue number
GA23351
Brand
GLPBIO
Computed properties PubChem CID 102062570 · XLogP -3.8 · TPSA 616 Ų · H-bond donors 20
XLogP
-3.8
TPSA
616 Ų
H-bond donors
20
H-bond acceptors
21
Rotatable bonds
51
Heavy atoms
114

SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C)N

Computed descriptors from PubChem (CID 102062570), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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