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Chemical structure of IFN-γ Antagonist

GA23098

IFN-γ Antagonist

Also known as (2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-1-[2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-3-(acetamidomethylsulfanyl)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-6-aminohexanoyl]amino]-3-methylpentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]-3-methylpentanoic acid

This peptide derived from the ligand binding site of the human γ-interferon (IFN-γ) receptor is an antagonist of human IFN-γ· It inhibited human IFN-γ-induced expression of HLR/DR antigen on Colo 205 cells with an approximate IC?? of 35 µM· Immobilized peptide specifically bound recombinant human IFN-γ (H-1728)· Tyrosine substitution at residue 121 allowed facile quantification and conjugation of the peptide

ChemicalCAS158040-83-6MW2629.08FormulaC115H194N34O34S
CAS number
158040-83-6
Molecular weight
2629.08
Formula
C115H194N34O34S
Solubility
Soluble in DMSO
InChIKey
MIQGNZNLJDUVPW-FPTMUGPJSA-N
Catalogue number
GA23098
Brand
GLPBIO
Computed properties PubChem CID 131698044 · XLogP -17.9 · TPSA 1150 Ų · H-bond donors 38
XLogP
-17.9
TPSA
1150 Ų
H-bond donors
38
H-bond acceptors
42
Rotatable bonds
94
Heavy atoms
184

SMILES CC[C@H](C)[C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CSCNC(=O)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C)N

Computed descriptors from PubChem (CID 131698044), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.