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Chemical structure of H-Pro-Phe-Arg-AMC

GA22857

H-Pro-Phe-Arg-AMC

Also known as (2S)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide

A highly sensitive, fluorogenic substrate for plasma as well as pancreatic and urinary kallikreins· PFR-AMC is also cleaved rapidly by soybean trypsin-like enzyme· Stock solutions of this substrate are best prepared in DMSO

ChemicalCAS65147-21-9MW575.67FormulaC30H37N7O5
CAS number
65147-21-9
Molecular weight
575.67
Formula
C30H37N7O5
Solubility
Soluble in DMSO
InChIKey
URNKXHHGSVKUKV-HJOGWXRNSA-N
Catalogue number
GA22857
Brand
GLPBIO
Computed properties PubChem CID 174085 · XLogP 1.6 · TPSA 190 Ų · H-bond donors 6
XLogP
1.6
TPSA
190 Ų
H-bond donors
6
H-bond acceptors
8
Rotatable bonds
12
Heavy atoms
42

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)N[C@@H](CCCN=C(N)N)C(=O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@@H]4CCCN4

Computed descriptors from PubChem (CID 174085), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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