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Chemical structure of H-Pro-Gly-Pro-OH

GA22843

H-Pro-Gly-Pro-OH

Also known as (2S)-1-[2-[[(2S)-pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid

H-Pro-Gly-Pro-OH (PGP) is a tripeptide generated from the breakdown of extracellular matrix collagen and is specifically chemotactic for neutrophils in vitro and in vivo· N-terminal acetylation of PGP (AcPGP - glpbio product H-6412) can enhance this chemotactic potential· PGP was identified as physiological substrate for the aminopeptidase activity of leukotriene A4 hydrolase· PGP is a biomarker for chronic obstructive pulmonary disease (COPD)

ChemicalCAS7561-51-5MW269.3FormulaC12H19N3O4
CAS number
7561-51-5
Molecular weight
269.3
Formula
C12H19N3O4
Solubility
H2O ： 125 mg/mL (464·17 mM; Need ultrasonic)
InChIKey
BRPMXFSTKXXNHF-IUCAKERBSA-N
Catalogue number
GA22843
Brand
GLPBIO
Computed properties PubChem CID 9903507 · XLogP -3 · TPSA 98.7 Ų · H-bond donors 3
XLogP
-3
TPSA
98.7 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
19

SMILES C1C[C@H](NC1)C(=O)NCC(=O)N2CCC[C@H]2C(=O)O

Computed descriptors from PubChem (CID 9903507), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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