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Chemical structure of H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH

GA22349

H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH

Also known as (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[5-(2-aminoethylamino)naphthalen-1-yl]sulfonylamino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-[[4-[[4-(dimethylamino)phenyl]diazenyl]benzoyl]amino]hexanoic acid

Internally quenched substrate for calpain-1 (µ-calpain) with optimal cleavage motifs flanking the scissile bond· The enzyme showed a more than 18-fold higher turnover rate for the hydrolysis of this FRET substrate based on the amino acid sequence PLFAER than for EVYGMM a sequence derived from the cleavage site of the natural substrate α-spectrin

ChemicalCAS1914987-47-5MW1488.73FormulaC72H97N17O16S
CAS number
1914987-47-5
Molecular weight
1488.73
Formula
C72H97N17O16S
Solubility
Soluble in DMSO
InChIKey
ZBTCIQPDYVIPOU-DAPRKCRDSA-N
Catalogue number
GA22349
Brand
GLPBIO
Computed properties PubChem CID 131698206 · XLogP 1.7 · TPSA 521 Ų · H-bond donors 15
XLogP
1.7
TPSA
521 Ų
H-bond donors
15
H-bond acceptors
23
Rotatable bonds
43
Heavy atoms
106

SMILES C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCNC(=O)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)N(C)C)C(=O)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCC(=O)O)NS(=O)(=O)C5=CC=CC6=C5C=CC=C6NCCN

Computed descriptors from PubChem (CID 131698206), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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