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Chemical structure of Hepcidin

GA22331

Hepcidin

Also listed as Hepcidin-25 (human)

Hepcidin-25 (hepatic bactericidal protein), also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine· The peptide which is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides that contain 8 cysteine residues and show significant antibacterial and antifungal activity· Further investigations revealed that hepicidin is the principal iron-regulatory hormone in humans· Hepcidin acts by binding to the iron exporter ferroportin, inducing its internalization and degradation, thereby blocking cellular iron efflux· Nemeth et al· demonstrated that the N-terminal part of the peptide hormone is essential for its activity· Former CAS-number 342790-21-0

ChemicalCAS1356390-47-0MW2789.4FormulaC113H170N34O31S9
CAS number
1356390-47-0
Molecular weight
2789.4
Formula
C113H170N34O31S9
Solubility
soluble in 1% Acetic Acid in 1mg/mL
InChIKey
XJOTXKZIRSHZQV-RXHOOSIZSA-N
Catalogue number
GA22331
Brand
GLPBIO
Computed properties PubChem CID 91864521 · XLogP -10.9 · TPSA 1250 Ų · H-bond donors 36
XLogP
-10.9
TPSA
1250 Ų
H-bond donors
36
H-bond acceptors
46
Rotatable bonds
49
Heavy atoms
187

SMILES CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H]4CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CC6=CC=CC=C6)NC(=O)[C@H](CC7=CNC=N7)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)N3)NC2=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC4=O)CC8=CNC=N8)CCCNC(=N)N)CO)CCCCN)CCSC)CC9=CC=CC=C9

Computed descriptors from PubChem (CID 91864521), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.